In healthy cells, EGFR triggers growth in response to an activating signal that comes from outside the cell. 在健康细胞中,EGFR通过感应来自细胞外的激活信号激发细胞生长。
The function of the inner circuit is for activating the transducer to produce the fixed frequency, and providing the high voltage and the signal of vibration for transducer. 机体内部的电路主要是为了激发压电陶瓷产生额定频率,而提供压电陶瓷要求的高电压及振荡信号。
The Na~+, K~+-ATPase make use of energy that ATP stores to guarantee transport and diffusion across cell membrane of Na~+ 、 K~+ ion. That is a basic step of activating nerval signal transfer and other vital process. Na+,K+-ATP酶利用ATP储存的能量来保证Na+、K+离子在膜内外的穿梭,而离子在膜内外的这种穿梭运动是启动神经信号传导和其它生命过程的基本步骤。
Conclusions EGF might promote the metastatic ability mainly by activating MAPK signal pathway in PC-3 cells. 结论EGF可能主要通过MAPK信号通路,从而促进PC-3细胞的的黏附、迁移和侵袭能力。
The results show some clues about how oncogene results in transformation of normal cells by activating signal transduction pathways. 综合这些信号转导途径的研究成果,可以看出bcr-abl活化癌基因和某些细胞因子,最终导致细胞癌变的一些规律。
CONCLUSION: The iNOS derived-NO through cGMP activating ERK kinase/ ERK/ P90RSK cell signal pathway induces injury of nerve cells after cerebral ischemical reperfusion injury. 结论:脑缺血再灌注损伤时,诱导型一氧化氮合酶源性的一氧化氮可能通过环磷酸鸟苷激活了细胞外信号调节激酶激酶/细胞外信号调节激酶/P90RSK信号转导通路诱导了神经细胞的损伤。
Conclusion EGCG induces apoptosis of BGC823 cells via activating mitochondrial signal transduction pathway. 结论EGCG通过活化线粒体信号传导途径诱导BGC823细胞凋亡。
LPS could regulate the expression of ICAM-1 gene and protein in HUVEC by activating p38 MAPK signal transduction passage. 结论LPS可能通过激活p38MAPK信号转导通路,调节HUVEC的ICAM-1基因和蛋白表达。
Recent Advances in Slit/ Robo GTPase Activating Proteins Signal Pathway in the Central Nervous System 中枢神经系统Slit/RoboGTPase激活蛋白信号通路研究进展
Arranged signal activating lock circuit and time-base control circuit in the sound wave receiving circuit to take the initial signal of back wave as the valid one in the cycle, thus to improve the ratio of signal vs. noise and detective precision. 在超声波接收电路中设有信号触发锁定电路和时基控制电路。实现以各探头中最早收到的回波信号为本检测单元的有效信号,有效提高信噪比和检测精度;
LPA influences target cells mainly by activating special G protein coupled receptors. The signal transduction system of LPA includes several known signal cascades: activating G q to stimulate PLC; LPA主要通过G蛋白偶联受体影响靶细胞功能,其信号转导系统包括已知的几条信号通路:激活Gq从而激活磷脂酶C;
Extracellular signal regulated kinase ( Erk), a member of MAPK family, could stimulate cell proliferation and restrain cell apoptosis by activating Ras-Raf-Mek-Erk signal cascade pathway. 细胞外信号调节蛋白激酶(ExtracellularSignalRegulatedKinase,Erk)是MAPK家族成员,通过Ras-Raf-MEK-Erk信号通路的激活促进细胞增殖,抑制细胞凋亡。
NK cells activating and inhibitory cell surface receptors specifically recognize their ligands on the target and trigger the subsequent signal transductions. Whether NK cell exert effector functions or be inhibited depends on the integration of both activating and inhibitory signals. ( 2) C shape; NK细胞通过其表面活化型受体和抑制型受体与相应配体特异识别,启动一系列信号转导,并且各种信号的整合效应决定着NK细胞是发挥效应功能,还是处于抑制状态。
Recent studies have indicated that three myelin-derived inhibitors including Nogo-A, MAG and OMgp all can inhibit axonal regeneration by activating the Rho-mediated signal transduction pathway. 研究表明,NogoA、MAG、OMgp等髓鞘源性的轴突再生抑制分子均可通过激活Rho介导的信号转导途径抑制轴突再生。
One molecular mechanism of skin photoaging is that UVA and UVB induce MMPs gene transcription of epidermal keratinocytes and dermal fibroblasts through activating cellular signal transduction pathways. 皮肤光老化的分子机制之一,是UVA和UVB通过激活细胞信号转导通路诱导表皮角质形成细胞和真皮成纤维细胞MMPs的基因转录。
LPA is a simple natural phospholipids secreted by a variety of cells to the cell surface, which activating its receptor, namely the specific GPCRs, activate the downstream signal pathways. LPA是一类由多种类型细胞分泌到细胞表面的结构简单的天然磷脂,通过激活其受体,即特定的GPCRs(LPA1),开启下游的信号通路。
Anyhow, obesity and intermittent hypoxia training both impact on cardiac structure and function by suppressing or activating on signal pathway in cardiac cells. 无论是肥胖或是间歇性低氧训练,它们对心肌细胞的结构和功能的一系列影响是通过对心肌细胞内多条信号通路进行激活或抑制实现的。
In somatic cells, binding uPA to uPAR may control cell proliferation, apoptosis, migration and chemotaxis by activating MAPKs signal pathway. 在体细胞,uPA通过结合其受体uPAR,可以触发MAPKs信号途径进而调控细胞增殖、凋亡、迁移、趋化等多种细胞功能。
Insulin-like growth factor-1 plays a role in neurons through activating multiple signal transduction pathways. 胰岛素样生长因子1可以通过激活多条信号转导通路对神经元发挥作用。
Through coupling and cytoplasmic tyrosine kinase JAK activating, Leptin receptor realizes signal transduction. 瘦素受体通过偶联和激活胞质酪氨酸激酶JAK(主要是JAK-1和JAK-2)而实现信号转导。
Macrophages are important cells in immunological system, having many functions such as presenting antigen, eliminating foreign body and secreting various cytokines, etc. They also have notable effects on activating and regulating T cells by co-stimulatory molecules and cytokines signal pathway. 巨噬细胞是免疫系统重要的细胞,有提呈抗原、清除异物及分泌多种细胞因子等作用。在通过共刺激分子和细胞因子信号途径激活和调节T细胞中发挥着独特的作用。